HS in Neural Diseases
We are studying 2 aspects of the involvement
of neural HS in disease processes - namely
its interactions with the Alzheimer precursor
protein (APP) and with prion proteins (responsible
for Transmissible Spongiform Encaphalopathies
- TSEs, including BSE in cows and new variant
CJD in humans). There is evidence that the
pathology of these diseases involves HS as
a component of the protein plaques which
form and damage the brain. A better understanding
of the functional roles of HS may open up
new therapeutic possibilities for these diseases.
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