HS and Growth Factors
Studies are directed to analysis of the fine
structure of HS chains (using novel sequencing
strategies) on HSPGs expressed in brain and
nervous tissues (and cell lines derived from
them) and their interactions with FGFs known
to have neuroregulatory functions (eg. 1,
2, 8 and 9). The saccharide specificity of
these interactions and also those with their
corresponding tyrosine kinase FGF receptors
are being studied. Prof. Heath (School of
Biosciences) is providing recombinant FGFs,
FGF receptors and cells transfected with
FGF receptors. In addition, studies on the
complex interaction of HS with these components
and its regulation of FGF signal transduction
are underway.
Refs:
Guimond, SE & Turnbull JE. (1999) Fibroblast
growth factor receptor signalling is dictated
by specific Heparan sulphate saccharides.
Current Biology 9, 1343-1346.
