HS in Neural Development
In these projects we are studying the structure
and biological activities of HS in the developing
nervous system, particularly the mouse (in
collaboration with Dr Miriam Ford-Perriss,
Anatomy & Cell Biology at Melbourne University)
but also in Xenopus (in collaboration with
Dr Christine Holt, Anatomy, Cambridge University).
Work includes the dynamic changes in the
structure of HS at different stages of development,
the altered functional capacities of this
HS (eg. growth factor binding and activation)
and altered expression of sulphotransferases
involved in HS biosynthesis (see other project
file on this topic).
Refs:
Brickman, Y., Nurcombe, V., Gallagher,
J.,
Ford, M. & Turnbull, JE. (1998)
Structural
modification of FGF-binding HS at a
determinative
stage of neuroepithelial development.
J. Biol. Chem. 273, 4350-4359.
Brickman, Y., Ford, M., Gallagher,
J., Nurcombe,
V., Bartlett, P., & Turnbull, JE.
(1998)
Structural comparison of FGF-specific
heparan
sulphates derived from a growing or
differentiating
neuroepithelial cell line. Glycobiology 8, 463-471.
