Group members
- Prof. Helen Cooper
- Dr Jinglei Yu
- Dr Todd Mize
- Dr Oliver Hale
- Dr Rebecca Edwards
- Dr Sarah Vickers
- Dr Cameron Baines
- Dr Yuying Du
- Edwin Aponte Angarita
- Peter Macey
- Sherzod Nazarov
Former group members
- Lewis Mapperley
- Dr Emma Sisley
- Dr James Hughes
- Dr Jana Havlikova
- Rebecca Davis
- Dr Eva Illes-Toth
- Dr Anna Simmonds
- Dr Rian Griffiths
- Dr Klaudia Kocurek
- Dr Tom Powell
- Gloria Ulasi
- Dr Andrea Lopez-Clavijo
- Dr Andrew Creese
- Dr Alex Dexter
- Dr Andrew Jones
- Dr Malgorzata Kaczorowska
- Dr Nick Martin
- Dr Victor Mikhailov
- Dr Elizabeth Randall
- Dr Joscelyn Sarsby
- Dr Steve Sweet
- Dr Cleidiane Zampronio
- Dr Hongyan Zhao
Dr Anna Simmonds
I am a Sci-Phy CDT student working on a PhD project that will develop mass spectrometry to probe the effect of phosphorylation on the structure of proteins implicated in ageing. The hypothesis is that measurements made on protein fragments can be reconstructed to determine protein structure, a kind of 'biomolecular tetris'. This will be achieved through studying salt bridges that arise from the interaction between phosphate groups and basic amino acid side-chains. Data from tandem mass spectrometry (MS-MS), ion mobility spectrometry (IMS) and computational studies will be combined into a multi-dimensional dataset that will be used to infer information about the tertiary structure of phosphoproteins.
Publications
https://orcid.org/0000-0001-8413-496X
2019
- A.L. Simmonds, A.F. Lopez-Clavijo, P.J. Winn, D.H. Russell, I.B. Styles and H.J. Cooper. Structural analysis of 14-3-3-ζ-derived phosphopeptides using electron capture dissociation mass spectrometry, travelling wave ion mobility spectrometry, and molecular modeling. The Journal of Physical Chemistry, 461-469.
2018
- R.L. Griffiths, A.L. Simmonds, J. Swales, R. Goodwin and H.J. Cooper. LESA MS imaging of heat preserved and frozen tissue: Benefits of multi-step static FAIMS. Analytical Chemistry, 13306-13314.
2017
- R.L. Griffiths, E.K. Sisley, A.F. Lopez-Clavijo, A.L. Simmonds, I.B. Styles and H.J. Cooper. Native mass spectrometry imaging of intact proteins and protein complexes in thin tissue sections. International Journal of Mass Spectrometry, 23-29.
